TB KaSPar
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TB is the main cause of hospitalization and mortality among people living with HIV. The assessment of the performance of an mWRD used as a combined TB screening and diagnostic strategy for medical ward patients with HIV included 4 studies in Ghana, Myanmar and South Africa with a total of 639 participants (see Web Annex B, Table 15, and Web Annex C, Table 8).
16. Among individuals younger than 15 years who are close contacts of someone with TB, systematic screening for TB disease should be conducted using a symptom screen including any one of cough, fever or poor weight gain; or chest radiography; or both
(new recommendation: strong recommendation, moderate to low certainty of evidence for test accuracy).
11. Among adults and adolescents living with HIV, systematic screening for TB disease should be conducted using the WHO-recommended four symptom screen and those who report any one of the symptoms of current cough, fever, weight loss or night sweats may have TB and should be evaluated for TB and other diseases
(existing recommendation: strong recommendation, moderate certainty of evidence).
12. Among adults and adolescents living with HIV, C-reactive protein with a cut-off of > 5 mg/L may be used to screen for TB disease
10. Among individuals aged 15 years and older in populations in which TB screening is recommended, computer-aided detection software programmes may be used in place of human readers for interpreting digital chest X-rays for screening and triage for TB disease
(new recommendation: conditional recommendation, low certainty of evidence).
9. Among individuals aged 15 years and older in populations in which TB screening is recommended, systematic screening for TB disease may be conducted using a symptom screen, chest X-ray or molecular WHO-recommended rapid diagnostic tests, alone or in combination
(new recommendation: conditional recommendation, very low certainty of evidence for test accuracy).
7. In settings where the TB prevalence in the general population is 100/100 000 population or higher, systematic screening for TB disease may be conducted among people with a risk factor for TB who are either seeking health care or who are already in care
(existing recommendation: conditional recommendation, very low certainty of evidence).
8. People with an untreated fibrotic lesion seen on chest X-ray may be systematically screened for TB disease
6. Current and former workers in workplaces with silica exposure should be systematically screened for TB disease
(existing recommendation: strong recommendation, low certainty of evidence).
5. Systematic screening for TB disease should be conducted in prisons and penitentiary institutions
(updated recommendation: strong recommendation, very low certainty of evidence).
