Comorbidities

This document was developed by Annabel Baddeley and Anna Carlqvist (consultant), with inputs from Kerri Viney, Matteo Zignol and Farai Mavhunga, under the overall direction of Tereza Kasaeva, director, all at the World Health Organization (WHO) Global Tuberculosis Programme.

Experts consulted during stakeholder consultation and external review

Globally, tuberculosis (TB) remains a significant cause of ill health and is a leading cause of death due to an infectious agent (1). The TB epidemic is attributable to five main health-related risk factors globally, namely, diabetes mellitus (diabetes), HIV, smoking, undernutrition, and disorders due to alcohol use. The contribution of these risk factors to the global TB burden is reported annually in the WHO global tuberculosis report (1).

1. Management of physical health conditions in adults with severe mental disorders: WHO guidelines. Geneva: World Health Organization; 2018 (https://iris.who.int/handle/10665/275718, accessed 27 October 2023).
2. WHO Mental Health Gap Action Programme (mhGAP) [website].

Mental health guidelines

• Management of physical health conditions in adults with severe mental disorders: WHO guidelines (1)
• WHO Website: WHO Mental Health Gap Action Programme (mhGAP) (2)
• mhGAP Intervention Guide for mental, neurological and substance use disorders in non-specialized health settings: mental health Gap Action Programme - Version 2.0 (3)

Brief biological interventions

1. Global tuberculosis report 2022. Geneva: World Health Organization; 2022 (https://www.who.int/publications/i/item/9789240061729).
2. Framework for collaborative action on tuberculosis and comorbidities. Geneva: World Health Organization; 2022 (https://www.who.int/publications/i/item/9789240055056).
3. The End TB Strategy.

TB often occurs along with other illnesses – not only mental disorders but also HIV, diabetes, hypertension and other conditions (70). These comorbidities are also independently associated with a higher risk of mental health problems (71). Health workers in TB and mental health services should endeavor to understand each person’s main priorities and concerns and support the treatment of both TB and mental disorders in order to comprehensively address the person’s needs.