Children and Adolescents

Unless otherwise specified, the terms defined here apply as used in this document. They may have different meanings in other contexts.

Active (tuberculosis) case-finding: Provider-initiated screening and testing in communities by mobile teams, often using mobile X-ray and rapid molecular tests. The term is sometimes used synonymously with "systematic screening".

The production and writing of the WHO consolidated guidelines on tuberculosis. Module 5: management of tuberculosis in children and adolescents, 2022 was coordinated by Sabine Verkuijl, Annemieke Brands, Kerri Viney and Tiziana Masini, under the guidance of Farai Mavhunga, head of the TB Vulnerable Populations, Communities and Comorbidities unit and the overall direction of Tereza Kasaeva, Director of the World Health Organization (WHO) Global Tuberculosis (TB) Programme.

Non-severe TB is defined as peripheral lymph node TB, intrathoracic lymph node TB without airway obstruction, uncomplicated TB pleural effusion or paucibacillary, non-cavitary disease confined to one lobe of the lungs and without a miliary pattern.

• Dosing guidance is based on currently available data and may be revised once additional data are available.
• For patients weighing ≥46 kg, please refer to Table A in Annex 1 of the WHO operational handbook on tuberculosis.

Infants aged under 3 months or weighing less than 3 kg (including premature birth (under 37 weeks) were not eligible for inclusion in the SHINE trial. No new data on treatment of congenital TB and very young infants aged 0–3 months with TB disease were received following a call for data.