FeedbackWeb Annex A
Web Annex A. Pharmacokinetics modelling and simulation studies for dosages of 6Lfx and 3HP https://doi.org/10.2471/B09127
Prevention
1.1 Risk assessment for tb laboratories: what is it?
The four-tier classification system of biosafety levels (1–4) described in WHO’s Laboratory biosafety manual² provides broad guidance on basic concepts of biosafety for the development of national and international codes of practice. The challenge for managers of TB programmes and staff at laboratories, particularly in resource-limited settings, has been to interpret the generic risk-group assignments and biosafety levels into specific precautions relevant to a country’s activities.
Definitions of terms
Aerosol-generating procedure
High-risk procedures that may increase the potential for generating droplet nuclei as a result of the mechanical force of the procedure(for example, pipetting, vortexing, centrifuging or mixing).
Airborne transmission
The transmission of disease caused by dissemination of droplet nuclei that remain infectious when suspended in air.
9. References
1. WHO handbook for guideline development. Geneva: World Health Organization, 2012.
2. Laboratory biosafety manual, 3rd edition. Geneva: World Health Organization, 2004 (WHO/CDS/CSR/LYO/2004.11). (Also available from http://www.who.int/csr/resources/publications/biosafety/en/Biosafety7.pdf.)
8.3 Spill clean-up kit
The laboratory manager is responsible for maintaining spill response kits. Two spill response kits should be prepared: one placed outside the containment laboratory and one placed inside the laboratory. The kits should include the items listed below.
Spill response kit: