Operational Handbooks

This document was developed by Annabel Baddeley and Anna Carlqvist (consultant), with inputs from Kerri Viney, Matteo Zignol and Farai Mavhunga, under the overall direction of Tereza Kasaeva, director, all at the World Health Organization (WHO) Global Tuberculosis Programme.

Experts consulted during stakeholder consultation and external review

Globally, tuberculosis (TB) remains a significant cause of ill health and is a leading cause of death due to an infectious agent (1). The TB epidemic is attributable to five main health-related risk factors globally, namely, diabetes mellitus (diabetes), HIV, smoking, undernutrition, and disorders due to alcohol use. The contribution of these risk factors to the global TB burden is reported annually in the WHO global tuberculosis report (1).

Web Annex B. Conflict of interest assessment for experts contributing to the handbook content https://doi.org/10.2471/B09117

Web Annex A. Pharmacokinetics modelling and simulation studies for dosages of 6Lfx and 3HP https://doi.org/10.2471/B09127

1. Houben RM, Dodd PJ. The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med. 2016;13:e1002152. doi: 10.1371/journal.pmed.1002152.

2. Global tuberculosis report 2020. Geneva: World Health Organization; 2020 (https://apps.who.int/iris/ bitstream/handle/10665/336069/9789240013131-eng.pdf, accessed 19 February 2021).