Systematic LTBI testing and treatment may be considered for prisoners, health workers,
immigrants from countries with a high TB burden, homeless people and people who use drugs.

People who are initiating anti-TNF treatment, or receiving dialysis, or preparing for an organ
or haematological transplant, or who have silicosis should be systematically tested and treated
for LTBI.

In selected high-risk household contacts of patients with multidrug-resistant tuberculosis,
preventive treatment may be considered based on individualized risk assessment and a sound
clinical justification.