Children and Adolescents

^{Note: these developmental assessment tools have not been formally adapted for use in low- and middle-income countries, and locally determined norms have not been developed. Interpretation of results requires careful consideration of the local context. A number of in-country locally developed screening tools are also available.}

• Dosing guidance is based on currently available data and may be revised once additional data are available.
• For patients weighing ≥46 kg, please refer to Table A in Annex 1 of the WHO operational handbook on tuberculosis.

Methodology for developing the treatment decision algorithms

This annex provides examples of standard operating procedures for the most common methods of obtaining clinical samples from children for rapid molecular testing: expectoration, gastric aspiration, nasopharyngeal aspiration (NPA) and sputum induction. 

This annex provides an overview of respiratory and non-respiratory specimens that can be used to diagnose TB in children and adolescents, with a short description for each, the age group in which they can be used, the minimum volume required for testing, and the optimal time of collection.

Roadmap

Roadmap towards ending TB in children and adolescents, second edition. Geneva: World Health Organization; 2018 (https://apps.who.int/iris/bitstream/handle/10665/275422/9789241514798-eng.
pdf?sequence=1&isAllowed=y).

WHO operational handbooks

WHO operational handbook on tuberculosis. Module 1: prevention – tuberculosis preventive treatment. Geneva: World Health Organization; 2020 (https://www.who.int/publications/i/item/9789240002906).

WHO provides guidance on the principles²⁹ and recommendations for nutritional care and support of people with TB as part of their regular TB care.

Five guiding principles are key for providing nutritional care and support as an integral part of TB care and prevention (105):