In populations with known or suspected high levels of isoniazid resistance, new
TB patients may receive HRE as therapy in the continuation phase as an acceptable alternative to HR.

Xpert MTB/RIF should be used rather than conventional microscopy, culture and drug
susceptibility testing (DST) as the initial diagnostic test in adults and children suspected of
having HIV-associated TB or multidrug resistant TB.

The following options are recommended for the treatment of LTBI regardless of HIV status:
6 or 9 months of daily isoniazid, or a 3-month regimen of weekly rifapentine plus isoniazid,
or a 3-month regimen of daily isoniazid plus rifampicin.

Bedaquiline should be included in longer MDR-TB regimens for patients aged 18 years or more. Bedaquiline may also be included in longer MDR-TB regimens for patients aged 6–17 years.