2. Reduce the burden of TB among people living with HIV

Tuberculosis remains the primary cause of HIV-related morbidity and mortality worldwide, despite impressive scale-up of ART. In 2022, an estimated 671 000 (uncertainty interval (UI): 600 000–746 000) people living with HIV developed TB disease, among whom only 426 958 (64%) were diagnosed and notified (1). In the same year, an estimated 167 000 (UI: 139 000–198 000) people living with HIV died from TB, representing 27% of all HIV-related deaths (1). A systematic review and meta-analysis of post-mortem studies of global HIV-related deaths found that TB was the primary cause of death in 37.2% of individuals (95% confidence interval (CI): 25.7–48.7%), and that TB remained undiagnosed prior to death in 45.8% of individuals (95% CI: 32.6–59.1%) (32).

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