5.2.3 Choice of fluoroquinolone

In terms of choice of fluoroquinolone, either levofloxacin or moxifloxacin may be used in the 9-month all-oral regimen, because they have shown similar efficacy for treating MDR/RR-TB. Although levofloxacin results in a higher pill burden, it is often preferred because moxifloxacin is associated with a higher risk of QT interval prolongation (49). Clinically significant, severe QT interval prolongation is relatively uncommon among patients treated with the 9-month all-oral regimens. However, the additive effect of co-administration of other QT-prolonging drugs (i.e. bedaquiline and clofazimine) within the shorter regimen should be considered when deciding on an appropriate regimen for individual patients with other risk factors for cardiotoxicity.

Navigation du livre