Structure of the chapter

The recommendations part of this chapter has four main sections on treatment of DS-TB. The elements covered are:

  • treatment of DS-TB using a 6-month regimen;
  • treatment of DS-TB using 4-month regimens;
  • DS-TB treatment and anti-retroviral therapy (ART) in people living with HIV (PLHIV); and
  • the use of adjuvant steroids in the treatment of TB meningitis and pericarditis.

Each section starts with the current WHO recommendations for that element. It then gives information on the evidence used to inform the recommendations, summarizes the analyses that were carried out based on the evidence, and describes considerations for specific subgroups, for monitoring and evaluation, and implementation. Research gaps that were identified for each of the sections are presented at the end of the document; web annexes provide more details on the methods, the GDGs, the reports of systematic reviews and data analyses, evidence profiles, unpublished data and statistical analysis plans. Each section reflects discussions held at GDG meetings. Additional information on implementing patient care interventions is presented in the relevant chapter of the WHO consolidated operational handbook on TB treatment and care (6), which is a separate document that is designed to aid implementation efforts.

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