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In selecting a diagnostic test to implement, it is important to consider the characteristics (i.e. risk factors) of the population being served. These characteristics should be derived from population-based studies, if available, and should include the proportion of:
- people with TB resistant to RIF, INH and FQs;
 - people living with HIV;
 - people with extrapulmonary TB;
 - children with TB;
 - people with acute illness requiring rapid diagnosis; and
 - people who are hospitalized versus those who are ambulatory.
 
Understanding the proportion resistant to a newly introduced drug (e.g. BDQ) is particularly important during the initial stages of using the drug, when treatment capacity may expand more rapidly than DST capacity.